Earlier today I listened to NPR’s broadcast of the Diane Rehm show: Implications of a Global Black Market for Botox (link removed 3/2017 -- no longer active). The guests were
In full disclosure, Diane Rehm begin by mentioning the use of Botox for her own vocal spasmotic dystonia. Very interesting show.Col. Randall Larsen, executive director of the bi-partisan, Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism and the founding director of The Institute for Homeland Security (2000-2003)Marina Voronova-Abrams, biosecurity or biothreat reduction expert, formerly based in Central Asia and Russia, now works for the nonprofit environmental group Global GreenDr. Tina Alster, clinical professor of dermatology at Georgetown University Medical Center and the Director of the Washington Institute of Dermatologic Laser Surgery.Kenneth Coleman, a Senior Fellow, for the Chemical & Biological Weapons Nonproliferation Program (CBWNP) of the James Martin Center for Nonproliferation Studies at the Monterey Institute of International Studies
….Obtaining the most lethal strain of the bacterium might have posed a significant hurdle for would-be terrorists in the recent past. But today, the prospect of tapping into the multibillion-dollar market for anti-wrinkle drugs has spawned an underground network of suppliers and distributors who do most of their transactions online, the researchers found. Customers don't need prescriptions or identification, other than a shipping address………..So lethal is the undiluted toxin that at least three countries -- the United States, the then-intact Soviet Union and Iraq -- explored its possible use as a possible biological or chemical weapon. All three gave up on the idea, partly because botulinum toxin degrades quickly when exposed to heat, making it poorly suited for delivery by missile or bomb
Botulinum toxin is the most poisonous substance known. A single gram of crystalline toxin, evenly dispersed and inhaled, would kill more than 1 million people, although technical factors would make such dissemination difficult. The basis of the phenomenal potency of botulinum toxin is enzymatic; the toxin is a zinc proteinase that cleaves 1 or more of the fusion proteins by which neuronal vesicles release acetylcholine into the neuromuscular junction.