In August 2008, FDA released a draft report finding that BPA remains safe in food contact materials. On October 31, 2008, a subcommittee of FDA's science board raised questions about whether FDA's review had adequately considered the most recent scientific information available. Most recently, on June 3, 2009, FDA Commissioner Dr. Margaret A. Hamburg testified before the House Committee on Energy and Commerce's Subcommittee on Health (written testimony is available at http://www.fda.gov/NewsEvents/Testimony/ucm164186.htm).In response to a question about BPA, Dr. Hamburg emphasized that she takes the questions that have been raised about BPA very seriously, and she stated that the FDA's new Acting Chief Scientist, Dr. Jesse Goodman, is working with FDA scientists to take a fresh look at the science of BPA. FDA intends to explain the results of this review in late summer or early fall.
Exposure of adults or infants to residual BPA through uses in food additives is relatively low (i.e., no more than 11 μg/person/day for any segment of the population). Traditionally, FDA’s evaluation of chemical migrants to food from the use of food contact materials at exposures of ≤ 150 μg/person/day focuses primarily on carcinogenicity and on genetic toxicity as an indicator of carcinogenicity1, unless data are available (biological or predictive) that indicate a concern for another endpoint of toxicity at this level.
It is well documented that BPA binds to estrogen receptors (ERα and ERβ), although its affinity is orders of magnitude lower than that of endogenous estrogen2,3. In addition, several in vitro studies have indicated that BPA may also interact with other receptors, including membrane bound ER and estrogen-related receptor γ (ERR γ)4. Since the late 1990s, a large volume of research has been generated suggesting a possible ‘low’ dose effect for weakly estrogenic environmental contaminants, such as BPA. The National Toxicology Program (NTP) defines ‘low’ dose for BPA as ≤ 5 mg/kg bw/day5
Listen to the briefing here at Better Health.
Bisphenol A in Plastics – Should We Worry? by Steven Novella (September 17, 2008)
Bisphenol A (BPA) -- FDA
FDA DRAFT Assessment of Bisphenol A for Use in Food Contact Applications (2008)
Pharmacokinetic Studies and Bisphenol A Metabolism