And this one (remember this study was done in Japan and I hope that the use of illegal silicone injection wouldn’t be done here in the U.S.)
Case 2A 37-year-old woman had undergone bilateral breast augmentation by autologous fat injection at a cosmetic clinic 3 years previously. Her breasts gradually became rigid and deformed, but she had no trouble with daily life. However, after having a child, she noticed an abnormal yellow secretion while breast-feeding. On her first visit to our facility, her breasts were clearly asymmetrical and deformed, and indurations were detected (Fig. 1). On mammography, computed tomography, and magnetic resonance imaging, large masses were detected in both breasts (Figs. 2 and 3). The tumors, which contained yellow fluid (Fig. 4), were removed surgically. Six months after the operation, both breasts were reconstructed with saline implants (Fig. 5). Abnormal breast secretion has not been observed since the masses were removed.
Case 12A 33-year-old woman underwent buttock liposuction and fat injection to the breast at a cosmetic clinic 2 years previously. After the operation, she became aware of indurations and disfiguration of both breasts and visited our facility. Asymmetry of the breasts and huge indurations were palpable (Fig. 18). On preoperative blood examination, high levels of antinuclear antibodies were detected. On mammography, huge masses were detected in the subcutaneous tissue (Fig. 19). Chest computed tomography revealed multiple low-density areas encapsulated with high-density areas in the subdermis in both breasts. Magnetic resonance imaging indicated multiple injected fat with high-iso signal intensity on T1-weighted images and low signal intensity on T2-weighted images (Fig. 20). Surgery to remove the subcutaneous masses was performed. Our routine examination for foreign bodies using nuclear magnetic resonance detected a small amount of silicone contamination. This suggests that the high levels of antinuclear antibodies in the blood may be the result of an immunologic reaction to silicone (human adjuvant diseases). These observations suggest that the patient had been injected with silicone at the time of surgery without her consent.
They give a very nice discussion of fat injection which includes some history
It appears that fat injection was first performed in 1893, when the German physician Franz Neuber9 used a small piece of upper arm fat to build up the face of a patient whose cheek bore a large pit caused by a tubercular inflammation of the underlying bone.
As a result, there remains a dearth of studies examining the long-term safety and efficacy of this technique. This technology, especially with regard to its use in breast augmentation, must be tested by multi-institutional long-term studies with careful breast cancer surveillance.
We believe that this has resulted in many victims, who are exemplified by the 12 patients that we have described in this article. The problems associated with this inadequately tested procedure are also exacerbated by a widespread decline in the skills of aesthetic surgeons because of the influx of many untrained and unskilled individuals, especially in some Asian countries, including Japan.
The complications associated with autologous fat grafting to the breast are well known, and include calcifications and oil cysts. These calcifications may mask or cover the microcalcifications associated with carcinomas. Remember fat grafting is “grafting” and there can be fat necrosis.
I admire their conclusions paragraph:
Autologous fat grafting to the breast is not a simple procedure and should be performed by well-trained and skilled surgeons. Patients should be informed that it is associated with a risk of calcification, multiple cyst formation, and indurations, and that breast cancer screens will always detect abnormalities. Patients should also be followed up over the long-term and imaging analyses (e.g., mammography, echography, computed tomography, and magnetic resonance imaging) should be performed.
Previous Post on Topic
Fat Injections for Breast Augmentation (November 6, 2008)